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What is lamivudine?

Lamivudine is a prescription medicine approved by the U.S. food and Drug Administration (FDA) for the treatment of HIV infection in adults and children 3 months of age and older. Lamivudine is always used in combination with other HIV medicines.

Lamivudine belongs to a group of HIV drugs called  nucleoside reverse transcriptase inhibitors (NRTIs). NRTIs block an HIV  enzyme called reverse transcriptase. By blocking reverse transcriptase, NRTIs prevent HIV from multiplying and can reduce the amount of HIV in the body.

HIV medicines can’t cure HIV/AIDS, but taking a combination of HIV medicines (called an HIV  treatment regimen) every day helps people with HIV live longer, healthier lives. HIV medicines also reduce the risk of HIV  transmission. If you are taking HIV medicines, including lamivudine, don’t cut down on, skip, or stop taking them unless your health care provider tells you to.

Lamivudine is also effective against  hepatitisvirus infection (HBV) in combination with other drugs and may be included in the HIV regimen of a person living with both HIV and HBV. However, if you have both HIV and HBV infection and take lamivudine, your HBV infection may get much worse (flare up) if you stop taking lamivudine. Do not stop taking lamivudine without first talking to your health care provider. For more information on the HBV-related use of lamivudine, please refer to the HBV section of the Guidelines for the Prevention and Treatment of Opportunistic Infections in Adults and Adolescents with HIV.

How should I take lamivudine?

Lamivudine (brand name: Epivir) comes in the following forms and strengths:

  • 150-mg tablets
  • 300-mg tablets
  • 10-mg/mL oral solution

Take lamivudine according to your health care provider’s instructions.

For children 3 months and older, their health care provider will prescribe a dose of lamivudine based on their body weight.

Take lamivudine by mouth, with or without food. Tell your health care provider if you or your child has trouble swallowing tablets. Lamivudine also comes as a liquid oral solution.

Always take lamivudine in combination with other HIV medicines.

If you take too much lamivudine, contact your health care provider or local poison control center (1-800-222-1222) right away, or go to the nearest hospital emergency room.

For more information on how to take lamivudine, see the FDA drug label.

Epivir-HBV is a different type of lamivudine approved by FDA for the treatment of chronic HBV infection in adults and children 2 years of age and older. You should not take Epivir-HBV if you have or may have HIV infection. (See section above: What are the most important things to know about lamivudine?)

What side effects can lamivudine cause?

Lamivudine may cause side effects. Many side effects from HIV medicines, such as nausea or occasional dizziness, are manageable. See the AIDSinfo fact sheet on HIV Medicines and Side Effects for more information

Some side effects of lamivudine can be serious. Serious side effects of lamivudine include a buildup of lactic acid in the blood (lactic acidosis), severe liver problems, and inflammation of the pancreas (pancreatitis) in children at risk for developing pancreatitis. (See section above: What are the most important things to know about lamivudine?)

Another possible side effect of lamivudine is changes in your  immune system (called  immune reconstitution inflammatory syndrome or IRIS). IRIS is a condition that sometimes occurs when the immune system begins to recover after treatment with an HIV medicine. As the immune system gets stronger, it may have an increased response to a previously hidden infection.

Tell your health care provider if you have any side effect that bothers you or that does not go away.

These are not all the possible side effects of lamivudine. To learn more about possible side effects of lamivudine, read the drug label or package insert or talk to your health care provider or pharmacist.

You can report side effects to FDA at 1-800-FDA-1088 (1-800-332-1088) or online or get back to use at

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