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What is efavirenz?

Efavirenz is a prescription medicine approved by the U.S.  Food and Drug Administration (FDA) for the treatment of HIV infection in adults and in children 3 months of age and older who weigh at least 7 lb 12 oz (3.5 kg). Efavirenz is always used in combination with other HIV medicines.

Efavirenz belongs to a group of HIV drugs called non- nucleoside  reverse transcriptase inhibitors (NNRTIs). NNRTIs attach to and block an HIV  enzyme called reverse transcriptase. By blocking reverse transcriptase, NNRTIs prevent HIV from multiplying and can reduce the amount of HIV in the body.

HIV medicines can’t cure HIV/AIDS, but taking a combination of HIV medicines (called an HIV  treatment regimen) every day helps people with HIV live longer, healthier lives. HIV medicines also reduce the risk of HIV  transmission. If you are taking HIV medicines, including efavirenz, don’t cut down on, skip, or stop taking them unless your health care provider tells you to.

What side effects can efavirenz cause?

Efavirenz may cause side effects. Many side effects from HIV medicines, such as nausea or occasional dizziness, are manageable. See the AIDSinfo fact sheet on HIV Medicines and Side Effects for more information.

Some side effects of efavirenz can be serious. Serious side effects of efavirenz include serious mental health problems, liver problems, and severe rash. (See section above: What are the most important things to know about efavirenz?)

Other possible side effects of efavirenz include:

  • Nervous system symptoms, including dizziness, drowsiness, trouble sleeping, unusual dreams, and trouble concentrating. (These symptoms usually go away within 2 to 4 weeks of beginning treatment. However, they may become worse if you drink alcohol, take a medicine for mental health problems, or use certain street drugs.)
  • Seizures, which are more likely to happen if you have had seizures in the past.
  • Changes in your immune system(called immune reconstitution inflammatory syndrome or IRIS). IRIS is a condition that sometimes occurs when the immune system begins to recover after treatment with an HIV medicine. As the immune system gets stronger, it may have an increased response to a previously hidden infection.
  • Changes in body fat (lipodystrophy syndrome).
  • Increases in the levels of certain fats (cholesterol and triglycerides) in the blood (hyperlipidemia).

Tell your health care provider if you have any side effect that bothers you or that does not go away.

These are not all the possible side effects of efavirenz. To learn more about possible side effects of efavirenz, read the drug label or package insert or talk to your health care provider or pharmacist.

You can report side effects to FDA at 1-800-FDA-1088 (1-800-332-1088) or online

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